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Isoniazid powde cas 54-85-3 with best price

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Use of Isoniazid  : Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid syn...


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    Use of Isoniazid  :

    Isoniazid is an antibacterial agent used primarily as a tuberculostatic.Target: AntibacterialIsoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG [1]. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824 [2, 3]. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing [4].

    Common Name Isoniazid
    CAS Number 54-85-3
    Density 1.2±0.1 g/cm3
    Melting Point 171-173 °C(lit.)
    Molecular Formula C6H7N3O
    Molecular Weight 137.139
    Flash Point >250°C
    Exact Mass 137.058914
    PSA 68.01
    LogP -0.89
    Index of Refraction 1.584
    Storage condition Refrigerator
    Water Solubility 14 g/100 mL (25 ºC)


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